Relevant Publications

2021
Unraveling the In Vivo Protein Corona
Simon, J., G. Kuhn, M. Fichter, S. Gehring, K. Landfester, and V. Mailander
Cells, 2021. 10(1).
Impact Factor: 4.366 more
2020
<h1 class="c-article-title" data-test="article-title" data-article-title="">An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma</h1>

Sahin, U., P. Oehm, E. Derhovanessian, R.A. Jabulowsky, M. Vormehr, M. Gold, D. Maurus, D. Schwarck-Kokarakis, A.N. Kuhn, T. Omokoko, L.M. Kranz, M. Diken, S. Kreiter, H. Haas, S. Attig, R. Rae, K. Cuk, A. Kemmer-Bruck, A. Breitkreuz, C. Tolliver, J. Caspar, J. Quinkhardt, L. Hebich, M. Stein, A. Hohberger, I. Vogler, I. Liebig, S. Renken, J. Sikorski, M. Leierer, V. Muller, H. Mitzel-Rink, M. Miederer, C. Huber, S. Grabbe, J. Utikal, A. Pinter, R. Kaufmann, J.C. Hassel, C. Loquai, and O. Tureci
Nature, 2020. 585(7823): p. 107-112.
Impact Facture: 42.778

<h1 class="title hypothesis_container">In Vivo siRNA Delivery to Immunosuppressive Liver Macrophages by α-Mannosyl-Functionalized Cationic Nanohydrogel Particles</h1>
Kaps, L., N. Leber, A. Klefenz, N. Choteschovsky, R. Zentel, L. Nuhn, and D. Schuppan
Cells, 2020. 9(8).
Impact Factor: 4.366 more
<h1 class="citation__title">Synergistic Anticancer Therapy by Ovalbumin Encapsulation‐Enabled Tandem Reactive Oxygen Species Generation</h1>
Jiang, S., M. Xiao, W. Sun, D. Crespy, V. Mailander, X. Peng, J. Fan, and K. Landfester
Angew Chem Int Ed Engl, 2020. 59(45): p. 20008-20016.
Impact Factor: 12.959 more
<h2 class="capsule__title fixpadv--m">Controlling protein interactions in blood for effective liver immunosuppressive therapy by silica nanocapsules</h2>
Jiang, S., D. Prozeller, J. Pereira, J. Simon, S. Han, S. Wirsching, M. Fichter, M. Mottola, I. Lieberwirth, S. Morsbach, V. Mailander, S. Gehring, D. Crespy, and K. Landfester
Nanoscale, 2020. 12(4): p. 2626-2637.
Impact Factor: 6.895 more
<h1 class="citation__title">Polymeric Nanoparticles with Neglectable Protein Corona</h1>
Alberg, I., S. Kramer, M. Schinnerer, Q. Hu, C. Seidl, C. Leps, N. Drude, D. Mockel, C. Rijcken, T. Lammers, M. Diken, M. Maskos, S. Morsbach, K. Landfester, S. Tenzer, M. Barz, and R. Zentel
Small, 2020. 16(18): p. e1907574.
Impact Factor: 11.459 more
<h1 class="article_header-title"><span class="hlFld-Title">Precision Anisotropic Brush Polymers by Sequence Controlled Chemistry</span></h1>

Chen, C., K. Wunderlich, D. Mukherji, K. Koynov, A.J. Heck, M. Raabe, M. Barz, G. Fytas, K. Kremer, D.Y.W. Ng, and T. Weil
J Am Chem Soc, 2020. 142(3): p. 1332-1340.
Impact Factor: 14.612

<h1 class="citation__title">Zebrafish Embryos Allow Prediction of Nanoparticle Circulation Times in Mice and Facilitate Quantification of Nanoparticle–Cell Interactions</h1>
Dal, N.K., A. Kocere, J. Wohlmann, S. Van Herck, T.A. Bauer, J. Resseguier, S. Bagherifam, H. Hyldmo, M. Barz, B.G. De Geest, and F. Fenaroli
Small, 2020. 16(5): p. e1906719.
Impact Factor: 11.459
<h1 class="citation__title">Integration of Indocyanine Green Analogs as Near‐Infrared Fluorescent Carrier for Precise Imaging‐Guided Gene Delivery</h1>
Liang, H., X. Chen, R. Jin, B. Ke, M. Barz, H. Ai, and Y. Nie
Small, 2020. 16(10): p. e1906538.
Impact Factor: 11.459
<h1 class="citation__title">DNA–Polymer Nanostructures by RAFT Polymerization and Polymerization‐Induced Self‐Assembly</h1>
Luckerath, T., K. Koynov, S. Loescher, C.J. Whitfield, L. Nuhn, A. Walther, C. Barner-Kowollik, D.Y.W. Ng, and T. Weil
Angew Chem Int Ed Engl, 2020. 59(36): p. 15474-15479.
Impact Factor: 12.959
<h1 class="citation__title">The Influence of Nanoparticle Shape on Protein Corona Formation</h1>
Madathiparambil Visalakshan, R., L.E. Gonzalez Garcia, M.R. Benzigar, A. Ghazaryan, J. Simon, A. Mierczynska-Vasilev, T.D. Michl, A. Vinu, V. Mailander, S. Morsbach, K. Landfester, and K. Vasilev
Small, 2020. 16(25): p. e2000285.
Impact Factor: 11.459
<h1 class="article_header-title"><span class="hlFld-Title"><em>Trans</em>-Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging</span></h1>
Steen, E.J.L., J.T. Jorgensen, K. Johann, K. Norregaard, B. Sohr, D. Svatunek, A. Birke, V. Shalgunov, P.E. Edem, R. Rossin, C. Seidl, F. Schmid, M.S. Robillard, J.L. Kristensen, H. Mikula, M. Barz, A. Kjaer, and M.M. Herth
ACS Nano, 2020. 14(1): p. 568-584.
Impact Factor: 14.588
<h1 class="citation__title">Amphiphilic Polyphenylene Dendron Conjugates for Surface Remodeling of Adenovirus 5</h1>
Wagner, J., L. Li, J. Simon, L. Krutzke, K. Landfester, V. Mailander, K. Mullen, D.Y.W. Ng, Y. Wu, and T. Weil
Angew Chem Int Ed Engl, 2020. 59(14): p. 5712-5720.
Impact Factor: 12.959
<h1 class="article_header-title"><span class="hlFld-Title">Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles</span></h1>
Wang, B., S. Van Herck, Y. Chen, X. Bai, Z. Zhong, K. Deswarte, B.N. Lambrecht, N.N. Sanders, S. Lienenklaus, H.W. Scheeren, S.A. David, F. Kiessling, T. Lammers, B.G. De Geest, and Y. Shi
J Am Chem Soc, 2020. 142(28): p. 12133-12139.
Impact Factor: 14.612
2019
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">Ligand density on nanoparticles: A parameter with critical impact on nanomedicine</span></h1>
Alkilany, A.M., L. Zhu, H. Weller, A. Mews, W.J. Parak, M. Barz, and N. Feliu
Adv Drug Deliv Rev, 2019. 143: p. 22-36.
Impact Factor: 13.30
<h1 class="citation__title">Poly(Sarcosine) Surface Modification Imparts Stealth‐Like Properties to Liposomes</h1>
Bleher, S., J. Buck, C. Muhl, S. Sieber, S. Barnert, D. Witzigmann, J. Huwyler, M. Barz, and R. Suss
Small, 2019. 15(50): p. e1904716.
Impact Factor: 11.459
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications</span></h1>

Dadfar, S.M., K. Roemhild, N.I. Drude, S. von Stillfried, R. Knuchel, F. Kiessling, and T. Lammers
Adv Drug Deliv Rev, 2019. 138: p. 302-325.
Impact Factor: 13.30

<h1 class="citation__title">Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer–Lipid Amphiphile Conjugates of Small‐Molecule TLR7/8 Agonists</h1>
De Vrieze, J., B. Louage, K. Deswarte, Z. Zhong, R. De Coen, S. Van Herck, L. Nuhn, C. Kaas Frich, A.N. Zelikin, S. Lienenklaus, N.N. Sanders, B.N. Lambrecht, S.A. David, and B.G. De Geest
Angew Chem Int Ed Engl, 2019. 58(43): p. 15390-15395.
Impact Factor: 12.959
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">Liver fibrosis affects the targeting properties of drug delivery systems to macrophage subsets in vivo</span></h1>
Ergen, C., P.M. Niemietz, F. Heymann, M. Baues, F. Gremse, R. Pola, L. van Bloois, G. Storm, F. Kiessling, C. Trautwein, T. Luedde, T. Lammers, and F. Tacke
Biomaterials, 2019. 206: p. 49-60.
Impact Factor: 10.317
<h1 class="article_header-title"><span class="hlFld-Title">High-Contrast Imaging of Nanodiamonds in Cells by Energy Filtered and Correlative Light-Electron Microscopy: Toward a Quantitative Nanoparticle-Cell Analysis</span></h1>
Han, S., M. Raabe, L. Hodgson, J. Mantell, P. Verkade, T. Lasser, K. Landfester, T. Weil, and I. Lieberwirth
Nano Lett, 2019. 19(3): p. 2178-2185.
Impact Factor: 11.238
<h1 class="citation__title">Prevention of Dominant IgG Adsorption on Nanocarriers in IgG‐Enriched Blood Plasma by Clusterin Precoating</h1>
Prozeller, D., J. Pereira, J. Simon, V. Mailander, S. Morsbach, and K. Landfester
Adv Sci (Weinh), 2019. 6(10): p. 1802199.
Impact Factor: 15.84
<h1 class="article_header-title"><span class="hlFld-Title">Combining Nanomedicine and Immunotherapy</span></h1>
Shi, Y. and T. Lammers
Acc Chem Res, 2019. 52(6): p. 1543-1554.
Impact Factor: 20.832
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">Investigation of charge ratio variation in mRNA – DEAE-dextran polyplex delivery systems</span></h1>
Siewert, C., H. Haas, T. Nawroth, A. Ziller, S.S. Nogueira, M.A. Schroer, C.E. Blanchet, D.I. Svergun, A. Radulescu, F. Bates, Y. Huesemann, M.P. Radsak, U. Sahin, and P. Langguth
Biomaterials, 2019. 192: p. 612-620.
Impact Factor: 10.317
<h1 class="citation__title">Noncovalent Targeting of Nanocarriers to Immune Cells with Polyphosphoester‐Based Surfactants in Human Blood Plasma</h1>
Simon, J., K.N. Bauer, J. Langhanki, T. Opatz, V. Mailander, K. Landfester, and F.R. Wurm
Adv Sci (Weinh), 2019. 6(22): p. 1901199.
Impact Factor: 15.84
<h2 class="capsule__title fixpadv--m">Nanomedicine and macroscale materials in immuno-oncology</h2>
Sun, Q., M. Barz, B.G. De Geest, M. Diken, W.E. Hennink, F. Kiessling, T. Lammers, and Y. Shi
Chem Soc Rev, 2019. 48(1): p. 351-381.
Impact Factor: 42.846
<h1 class="c-article-title" data-test="article-title" data-article-title="">Smart cancer nanomedicine</h1>
van der Meel, R., E. Sulheim, Y. Shi, F. Kiessling, W.J.M. Mulder, and T. Lammers
Nat Nanotechnol, 2019. 14(11): p. 1007-1017.
Impact Factor: 31.538
<h1 class="citation__title">Possibilities and Limitations of Different Separation Techniques for the Analysis of the Protein Corona</h1>
Weber, C., S. Morsbach, and K. Landfester
Angew Chem Int Ed Engl, 2019. 58(37): p. 12787-12794.
Impact Factor: 12.959
2018
<h1 class="c-article-title" data-test="article-title" data-article-title="">Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages</h1>
Bohn, T., S. Rapp, N. Luther, M. Klein, T.J. Bruehl, N. Kojima, P. Aranda Lopez, J. Hahlbrock, S. Muth, S. Endo, S. Pektor, A. Brand, K. Renner, V. Popp, K. Gerlach, D. Vogel, C. Lueckel, D. Arnold-Schild, J. Pouyssegur, M. Kreutz, M. Huber, J. Koenig, B. Weigmann, H.C. Probst, E. von Stebut, C. Becker, H. Schild, E. Schmitt, and T. Bopp
Nat Immunol, 2018. 19(12): p. 1319-1329.
Impact Factor: 20.479
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">Tumor targeting via EPR: Strategies to enhance patient responses</span></h1>
Golombek, S.K., J.N. May, B. Theek, L. Appold, N. Drude, F. Kiessling, and T. Lammers
Adv Drug Deliv Rev, 2018. 130: p. 17-38.
Impact Factor: 13.30
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">Folate receptor-directed orthogonal click-functionalization of siRNA lipopolyplexes for tumor cell killing <em>in vivo</em></span></h1>
Klein, P.M., S. Kern, D.J. Lee, J. Schmaus, M. Hohn, J. Gorges, U. Kazmaier, and E. Wagner
Biomaterials, 2018. 178: p. 630-642.
Impact Factor: 10.317
<h1 class="citation__title">Protein‐Corona‐by‐Design in 2D: A Reliable Platform to Decode Bio–Nano Interactions for the Next‐Generation Quality‐by‐Design Nanomedicines</h1>
Mei, K.C., A. Ghazaryan, E.Z. Teoh, H.D. Summers, Y. Li, B. Ballesteros, J. Piasecka, A. Walters, R.C. Hider, V. Mailander, and K.T. Al-Jamal
Adv Mater, 2018: p. e1802732.
Impact Factor: 27.398
<h1 class="citation__title">Engineering Proteins at Interfaces: From Complementary Characterization to Material Surfaces with Designed Functions</h1>
Morsbach, S., G. Gonella, V. Mailander, S. Wegner, S. Wu, T. Weidner, R. Berger, K. Koynov, D. Vollmer, N. Encinas, S.L. Kuan, T. Bereau, K. Kremer, T. Weil, M. Bonn, H.J. Butt, and K. Landfester
Angew Chem Int Ed Engl, 2018. 57(39): p. 12626-12648.
Impact Factor: 12.959
<h1 class="c-article-title" data-test="article-title" data-article-title="">Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy</h1>
Negwer, I., A. Best, M. Schinnerer, O. Schafer, L. Capeloa, M. Wagner, M. Schmidt, V. Mailander, M. Helm, M. Barz, H.J. Butt, and K. Koynov
Nat Commun, 2018. 9(1): p. 5306.
Impact Factor: 12.121
<h1 class="citation__title">Nanoparticle‐Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses</h1>

Nuhn, L., S. De Koker, S. Van Lint, Z. Zhong, J.P. Catani, F. Combes, K. Deswarte, Y. Li, B.N. Lambrecht, S. Lienenklaus, N.N. Sanders, S.A. David, J. Tavernier, and B.G. De Geest
Adv Mater, 2018. 30(45): p. e1803397.
Impact Factor: 27.398

<h1 class="citation__title">FRET Monitoring of Intracellular Ketal Hydrolysis in Synthetic Nanoparticles</h1>
Nuhn, L., S. Van Herck, A. Best, K. Deswarte, M. Kokkinopoulou, I. Lieberwirth, K. Koynov, B.N. Lambrecht, and B.G. De Geest
Angew Chem Int Ed Engl, 2018. 57(33): p. 10760-10764.
Impact Factor: 12.959
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist</span></h1>
Nuhn, L., L. Van Hoecke, K. Deswarte, B. Schepens, Y. Li, B.N. Lambrecht, S. De Koker, S.A. David, X. Saelens, and B.G. De Geest
Biomaterials, 2018. 178: p. 643-651.
Impact Factor: 10.317
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">Protein corona–mediated targeting of nanocarriers to B cells allows redirection of allergic immune responses</span></h1>
hen, L., S. Tenzer, W. Storck, D. Hobernik, V.K. Raker, K. Fischer, S. Decker, A. Dzionek, S. Krauthauser, M. Diken, A. Nikolaev, J. Maxeiner, P. Schuster, C. Kappel, A. Verschoor, H. Schild, S. Grabbe, and M. Bros
J Allergy Clin Immunol, 2018. 142(5): p. 1558-1570.
Impact Factor: 14.11
<h1 class="citation__title">Hydrophilicity Regulates the Stealth Properties of Polyphosphoester‐Coated Nanocarriers</h1>
Simon, J., T. Wolf, K. Klein, K. Landfester, F.R. Wurm, and V. Mailander
Angew Chem Int Ed Engl, 2018. 57(19): p. 5548-5553.
Impact Factor: 12.959
<h1 class="c-article-title" data-test="article-title" data-article-title="">Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona</h1>
Tonigold, M., J. Simon, D. Estupinan, M. Kokkinopoulou, J. Reinholz, U. Kintzel, A. Kaltbeitzel, P. Renz, M.P. Domogalla, K. Steinbrink, I. Lieberwirth, D. Crespy, K. Landfester, and V. Mailander
Nanotechnol, 2018. 13(9): p. 862-869.
Impact Factor: 31.538
<h1 class="article_header-title"><span class="hlFld-Title">Lymph-Node-Targeted Immune Activation by Engineered Block Copolymer Amphiphiles–TLR7/8 Agonist Conjugates</span></h1>
Van Herck, S., K. Deswarte, L. Nuhn, Z. Zhong, J.P. Portela Catani, Y. Li, N.N. Sanders, S. Lienenklaus, S. De Koker, B.N. Lambrecht, S.A. David, and B.G. De Geest
J Am Chem Soc, 2018. 140(43): p. 14300-14307.
Impact Factor: 14.612
2017
<span style="line-height: 107%; font-family: 'Calibri',sans-serif; font-size: 11pt; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: Calibri; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;" lang="EN-US"><span style="color: #0d4d7b; line-height: 107%; font-family: 'Times New Roman',serif; font-size: 18pt; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: EN-US; mso-fareast-language: DE; mso-bidi-language: AR-SA; mso-font-kerning: 18.0pt; mso-bidi-font-weight: bold; mso-bidi-font-size: 14.5pt;" lang="EN-US">Recent advances in the use of nanoparticles for allergen-specific immunotherapy</span></span>

Pohlit, H., I. Bellinghausen, H. Frey, and J. Saloga 
Allergy, 2017. 72: p. 1461-74.
Impact Factor: 6.048

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<span style="color: #0d4d7b; line-height: 107%; font-family: 'Times New Roman',serif; font-size: 18pt; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: EN-US; mso-fareast-language: DE; mso-bidi-language: AR-SA; mso-font-kerning: 18.0pt; mso-bidi-font-weight: bold; mso-bidi-font-size: 14.5pt;" lang="EN-US">Poly(Ethylene Glycol)Dimethacrylates with Cleavable Ketal Sites: Precursors for Cleavable PEG-Hydrogels</span>

Pohlit, H., D. Leibig, and H. Frey 
Macromol Biosci, 2017.
Impact Factor: 3.392

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<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">SiRNA-mediated <em>in vivo</em> gene knockdown by acid-degradable cationic nanohydrogel particles</span></h1>
Leber, N., L. Kaps, M. Aslam, J. Schupp, A. Brose, D. Schaffel, K. Fischer, M. Diken, D. Strand, K. Koynov, A. Tuettenberg, L. Nuhn, R. Zentel, and D. Schuppan
J Control Release, 2017. 248: p. 10-23.
Impact Factor: 7.877 more
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">Targeting distinct myeloid cell populations in vivo using polymers, liposomes and microbubbles</span></h1>
Ergen, C., F. Heymann, W. Al Rawashdeh, F. Gremse, M. Bartneck, U. Panzer, R. Pola, M. Pechar, G. Storm, N. Mohr, M. Barz, R. Zentel, F. Kiessling, C. Trautwein, T. Lammers, and F. Tacke
Biomaterials, 2017. 114: p. 106-120.
Impact Factor: 10.317 more
<h1 class="article_header-title"><span class="hlFld-Title">Immunomodulatory Therapy of Inflammatory Liver Disease Using Selectin-Binding Glycopolymers</span></h1>
Bartneck, M., C.T. Schlosser, M. Barz, R. Zentel, C. Trautwein, T. Lammers, and F. Tacke
ACS Nano, 2017. 11(10): p. 9689-9700.
Impact Factor: 14.588
<h1 class="citation__title">The Influence of Block Ionomer Microstructure on Polyplex Properties: Can Simulations Help to Understand Differences in Transfection Efficiency?</h1>
Heller, P., J. Zhou, B. Weber, D. Hobernik, M. Bros, F. Schmid, and M. Barz
Small, 2017. 13(17).
Impact Factor: 11.459
<h1 class="citation__title">Secondary‐Structure‐Driven Self‐Assembly of Reactive Polypept(o)ides: Controlling Size, Shape, and Function of Core Cross‐Linked Nanostructures</h1>
Klinker, K., O. Schafer, D. Huesmann, T. Bauer, L. Capeloa, L. Braun, N. Stergiou, M. Schinnerer, A. Dirisala, K. Miyata, K. Osada, H. Cabral, K. Kataoka, and M. Barz
Angew Chem Int Ed Engl, 2017. 56(32): p. 9608-9613.
Impact Factor: 12.959
<h1 class="citation__title">Polymeric Selectin Ligands Mimicking Complex Carbohydrates: From Selectin Binders to Modifiers of Macrophage Migration</h1>
Moog, K.E., M. Barz, M. Bartneck, F. Beceren-Braun, N. Mohr, Z. Wu, L. Braun, J. Dernedde, E.A. Liehn, F. Tacke, T. Lammers, H. Kunz, and R. Zentel
Angew Chem Int Ed Engl, 2017. 56(5): p. 1416-1421.
Impact Factor: 12.959
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">Coating nanoparticles with tunable surfactants facilitates control over the protein corona</span></h1>
Müller, J., K.N. Bauer, D. Prozeller, J. Simon, V. Mailänder, F.R. Wurm, S. Winzen, and K. Landfester
Biomaterials, 2017. 115: p. 1-8.
Impact Factor: 10.317
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">Pharmacological and physical vessel modulation strategies to improve EPR-mediated drug targeting to tumors</span></h1>
Ojha, T., V. Pathak, Y. Shi, W.E. Hennink, C.T.W. Moonen, G. Storm, F. Kiessling, and T. Lammers
Adv Drug Deliv Rev, 2017. 119: p. 44-60.
Impact Factor: 13.30
<h1 class="c-article-title" data-test="article-title" data-article-title="">Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer</h1>
Sahin, U., E. Derhovanessian, M. Miller, B.P. Kloke, P. Simon, M. Lower, V. Bukur, A.D. Tadmor, U. Luxemburger, B. Schrors, T. Omokoko, M. Vormehr, C. Albrecht, A. Paruzynski, A.N. Kuhn, J. Buck, S. Heesch, K.H. Schreeb, F. Muller, I. Ortseifer, I. Vogler, E. Godehardt, S. Attig, R. Rae, A. Breitkreuz, C. Tolliver, M. Suchan, G. Martic, A. Hohberger, P. Sorn, J. Diekmann, J. Ciesla, O. Waksmann, A.K. Bruck, M. Witt, M. Zillgen, A. Rothermel, B. Kasemann, D. Langer, S. Bolte, M. Diken, S. Kreiter, R. Nemecek, C. Gebhardt, S. Grabbe, C. Holler, J. Utikal, C. Huber, C. Loquai, and O. Tureci
Nature, 2017. 547(7662): p. 222-226.
Impact Factor: 42.778
<h1 class="article_header-title"><span class="hlFld-Title">Balancing Passive and Active Targeting to Different Tumor Compartments Using Riboflavin-Functionalized Polymeric Nanocarriers</span></h1>
Tsvetkova, Y., N. Beztsinna, M. Baues, D. Klein, A. Rix, S.K. Golombek, W. Al Rawashdeh, F. Gremse, M. Barz, K. Koynov, S. Banala, W. Lederle, T. Lammers, and F. Kiessling
Nano Lett, 2017. 17(8): p. 4665-4674.
Impact Factor: 11.238
2016

Pohlit, H, H. Frey, and J. Saloga
Nanomedicine, 2016. 11: p. 1329-31.
Impact Factor: 4.727

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<p><span style="line-height: 107%; font-family: 'Calibri',sans-serif; font-size: 11pt; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: Calibri; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;" lang="EN-US"><span style="line-height: 107%; font-family: 'Calibri',sans-serif; font-size: 11pt; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: Calibri; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;" lang="EN-US"><span style="color: #0d4d7b; line-height: 107%; font-family: 'Times New Roman',serif; font-size: 18pt; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: DE; mso-fareast-language: DE; mso-bidi-language: AR-SA; mso-font-kerning: 18.0pt; mso-bidi-font-weight: bold; mso-bidi-font-size: 14.5pt;">Polymerization of Ethylene Oxide, Propylene Oxide, and Other Alkylene Oxides: Synthesis, Novel<br />Polymer Architectures, and Bioconjugation</span></span></span></p>

Herzberger, J, K.  Niederer, H. Pohlit, J. Seiwert, M. Worm, F.R. Wurm, and H. Frey
Chem Rev, 2016. 116: p. 2170-243.
Impact Factor: 47.928

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<h1 class="heading-title">Vaccination with trifunctional nanoparticles that address CD8 <sup>+</sup> dendritic cells inhibits growth of established melanoma</h1>
Shen, L., S. Krauthauser, K. Fischer, D. Hobernik, Y. Abassi, A. Dzionek, A. Nikolaev, N. Voltz, M. Diken, M. Krummen, E. Montermann, I. Tubbe, S. Lorenz, D. Strand, H. Schild, S. Grabbe, and M. Bros
Nanomedicine (Lond), 2016. 11(20): p. 2647-2662.
Impact Factor: 4.727 more
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">MPLA-coated hepatitis B virus surface antigen (HBsAg) nanocapsules induce vigorous T cell responses in cord blood derived human T cells</span></h1>
Pietrzak-Nguyen, A., K. Piradashvili, M. Fichter, L. Pretsch, F. Zepp, F.R. Wurm, K. Landfester, and S. Gehring
Nanomedicine, 2016. 12(8): p. 2383-2394.
Impact Factor: 5.182 more
<h1 class="citation__title">Design and Control of Nanoconfinement to Achieve Magnetic Resonance Contrast Agents with High Relaxivity</h1>
Malzahn, K., S. Ebert, I. Schlegel, O. Neudert, M. Wagner, G. Schutz, A. Ide, F. Roohi, K. Munnemann, D. Crespy, and K. Landfester
Advanced Healthcare Materials, 2016. 5(5): p. 567-574.
Impact Factor: 6.270 more
<h1 class="c-article-title" data-test="article-title" data-article-title="">Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy</h1>
Kranz, L.M., M. Diken, H. Haas, S. Kreiter, C. Loquai, K.C. Reuter, M. Meng, D. Fritz, F. Vascotto, H. Hefesha, C. Grunwitz, M. Vormehr, Y. Husemann, A. Selmi, A.N. Kuhn, J. Buck, E. Derhovanessian, R. Rae, S. Attig, J. Diekmann, R.A. Jabulowsky, S. Heesch, J. Hassel, P. Langguth, S. Grabbe, C. Huber, O. Tureci, and U. Sahin
Nature, 2016. 534(7607): p. 396-401.
Impact Factor: 42.778 more
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">Polymeric hepatitis C virus non-structural protein 5A nanocapsules induce intrahepatic antigen-specific immune responses</span></h1>
Fichter, M., K. Piradashvili, A. Pietrzak-Nguyen, L. Pretsch, G. Kuhn, S. Strand, M. Knuf, F. Zepp, F.R. Wurm, V. Mailander, K. Landfester, and S. Gehring
Biomaterials, 2016. 108: p. 1-12.
Impact Factor: 10.317 more
<h1 class="citation__title">Amphiphilic Copolymers Shuttle Drugs Across the Blood–Brain Barrier</h1>
Clemens-Hemmelmann, M., C. Kuffner, V. Metz, L. Kircher, U. Schmitt, C. Hiemke, R. Postina, and R. Zentel
Macromolecular Bioscience, 2016. 16(5): p. 655-665.
Impact Factor: 3.416 more
<h1 class="article_header-title"><span class="hlFld-Title">Glutathione Responsive Hyaluronic Acid Nanocapsules Obtained by Bioorthogonal Interfacial “Click” Reaction</span></h1>
Baier, G., M. Fichter, A. Kreyes, K. Klein, V. Mailander, S. Gehring, and K. Landfester
Biomacromolecules, 2016. 17(1): p. 148-53.
Impact Factor: 6.092 more
2015
<p><span style="line-height: 107%; font-family: 'Calibri',sans-serif; font-size: 11pt; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: Calibri; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;" lang="EN-US"><span style="line-height: 107%; font-family: 'Arial',sans-serif; font-size: 11pt; mso-fareast-font-family: Calibri; mso-fareast-theme-font: minor-latin; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA; mso-no-proof: yes;" lang="EN-US"><span style="color: #000000;"><span style="color: #0d4d7b; line-height: 107%; font-family: 'Verdana',sans-serif; font-size: 14.5pt; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: Helvetica; mso-ansi-language: DE; mso-fareast-language: DE; mso-bidi-language: AR-SA; mso-font-kerning: 18.0pt;"><span style="color: #0d4d7b; line-height: 107%; font-family: 'Times New Roman',serif; font-size: 14.5pt; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: DE; mso-fareast-language: DE; mso-bidi-language: AR-SA; mso-font-kerning: 18.0pt; mso-bidi-font-weight: bold;"><span style="color: #0d4d7b; line-height: 107%; font-family: 'Times New Roman',serif; font-size: 16pt; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: DE; mso-fareast-language: DE; mso-bidi-language: AR-SA; mso-font-kerning: 18.0pt; mso-bidi-font-weight: bold; mso-bidi-font-size: 14.5pt;"><span style="color: #0d4d7b; line-height: 107%; font-family: 'Times New Roman',serif; font-size: 18pt; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: DE; mso-fareast-language: DE; mso-bidi-language: AR-SA; mso-font-kerning: 18.0pt; mso-bidi-font-weight: bold; mso-bidi-font-size: 14.5pt;">Biodegradable pH-Sensitive Poly(ethylene glycol) Nanocarriers for Allergen Encapsulation and<br />Controlled Release</span></span></span></span></span></span></span></p>

Pohlit, H, I. Bellinghausen, M. Schömer, B. Heydenreich, J. Saloga, and H. Frey
Biomacromolecules, 2015. 16: p. 3103-11.
Impact Factor: 5.583

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<h1 class="article_header-title"><span class="hlFld-Title">Biodegradable Protein Nanocontainers</span></h1>
Piradashvili, K., M. Fichter, K. Mohr, S. Gehring, F.R. Wurm, and K. Landfester
Biomacromolecules, 2015. 16(3): p. 815-21.
Impact Factor: 6.092 more
<h1 class="citation__title">In Vivo Gene‐Silencing in Fibrotic Liver by siRNA‐Loaded Cationic Nanohydrogel Particles</h1>
Kaps, L., L. Nuhn, M. Aslam, A. Brose, F. Foerster, S. Rosigkeit, P. Renz, R. Heck, Y.O. Kim, I. Lieberwirth, D. Schuppan, and R. Zentel
Advanced Healthcare Materials, 2015. 4(18): p. 2809-2815.
Impact Factor: 6.270 more
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">Tailoring the stealth properties of biocompatible polysaccharide nanocontainers</span></h1>
Kang, B., P. Okwieka, S. Schottler, O. Seifert, R.E. Kontermann, K. Pfizenmaier, A. Musyanovych, R. Meyer, M. Diken, U. Sahin, V. Mailander, F.R. Wurm, and K. Landfester
Biomaterials, 2015. 49: p. 125-34.
Impact Factor: 10.317 more
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">Monophosphoryl lipid A coating of hydroxyethyl starch nanocapsules drastically increases uptake and maturation by dendritic cells while minimizing the adjuvant dosage</span></h1>
Fichter, M., M. Dedters, A. Pietrzak-Nguyen, L. Pretsch, C.U. Meyer, S. Strand, F. Zepp, G. Baier, K. Landfester, and S. Gehring
Vaccine, 2015. 33(7): p. 838-46.
Impact Factor: 3.143 more
<h1 class="citation__title">Heparin‐Based Nanocapsules as Potential Drug Delivery Systems</h1>
Baier, G., S. Winzen, C. Messerschmidt, D. Frank, M. Fichter, S. Gehring, V. Mailander, and K. Landfester
Macromol Biosci, 2015. 15(6): p. 765-76.
Impact Factor: 3.416 more
2014
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">Bioactive and biodegradable silica biomaterial for bone regeneration</span></h1>
Wang, S., X. Wang, F.G. Draenert, O. Albert, H.C. Schroder, V. Mailander, G. Mitov, and W.E. Muller
Bone, 2014. 67: p. 292-304.
Impact Factor: 4.455 more
<h1 class="article_header-title"><span class="hlFld-Title">Enhanced in Vivo Targeting of Murine Nonparenchymal Liver Cells with Monophosphoryl Lipid A Functionalized Microcapsules</span></h1>
Pietrzak-Nguyen, A., M. Fichter, M. Dedters, L. Pretsch, S.H. Gregory, C. Meyer, A. Doganci, M. Diken, K. Landfester, G. Baier, and S. Gehring
Biomacromolecules, 2014. 15(7): p. 2378-88.
Impact Factor: 6.092 more
2013
<h1 id="artTitle">A Trifunctional Dextran-Based Nanovaccine Targets and Activates Murine Dendritic Cells, and Induces Potent Cellular and Humoral Immune Responses <em>In Vivo</em></h1>
Shen, L., T. Higuchi, I. Tubbe, N. Voltz, M. Krummen, S. Pektor, E. Montermann, K. Rausch, M. Schmidt, H. Schild, S. Grabbe, and M. Bros
PLoS One, 2013. 8(12): p. e80904.
Impact Factor: 2.740 more
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">Nanocapsules generated out of a polymeric dexamethasone shell suppress the inflammatory response of liver macrophages</span></h1>
Fichter, M., G. Baier, M. Dedters, L. Pretsch, A. Pietrzak-Nguyen, K. Landfester, and S. Gehring
Nanomedicine, 2013. 9(8): p. 1223-34.
Impact Factor: 5.182 more
<h1 class="citation__title">Contrasting responses of Kupffer cells and inflammatory mononuclear phagocytes to biliary obstruction in a mouse model of cholestatic liver injury</h1>
Duwaerts, C.C., S. Gehring, C.W. Cheng, N. van Rooijen, and S.H. Gregory
Liver Int, 2013. 33(2): p. 255-65.
Impact Factor: 5.20 more
<h1 class="article_header-title"><span class="hlFld-Title">HPMA-LMA Copolymer Drug Carriers in Oncology: An in Vivo PET Study to Assess the Tumor Line-Specific Polymer Uptake and Body Distribution</span></h1>
Allmeroth, M., D. Moderegger, D. Gundel, K. Koynov, H.G. Buchholz, K. Mohr, F. Rosch, R. Zentel, and O. Thews
Biomacromolecules, 2013. 14(9): p. 3091-3101.
Impact Factor: 6.092 more
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">PEGylation of HPMA-based block copolymers enhances tumor accumulation <em>in vivo</em>: A quantitative study using radiolabeling and positron emission tomography</span></h1>
Allmeroth, M., D. Moderegger, D. Gundel, H.G. Buchholz, N. Mohr, K. Koynov, F. Rosch, O. Thews, and R. Zentel
Journal of Controlled Release, 2013. 172(1): p. 77-85.
Impact Factor: 7.877 more
2011
<h1 class="article_header-title"><span class="hlFld-Title">Modifying the Body Distribution of HPMA-Based Copolymers by Molecular Weight and Aggregate Formation</span></h1>
Allmeroth, M., D. Moderegger, B. Biesalski, K. Koynov, F. Rosch, O. Thews, and R. Zentel
Biomacromolecules, 2011. 12(7): p. 2841-2849.
Impact Factor: 6.092 more
2009
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">Invariant Natural Killer T Cells Suppress the Neutrophil Inflammatory Response in a Mouse Model of Cholestatic Liver Damage</span></h1>
Wintermeyer, P., C.W. Cheng, S. Gehring, B.L. Hoffman, M. Holub, L. Brossay, and S.H. Gregory
Gastroenterology, 2009. 136(3): p. 1048-59.
Impact Factor: 15.13 more
Laser capture microdissection and genetic analysis of carbon-labeled Kupffer cells
Gehring, S., E. Sabo, M.E. San Martin, E.M. Dickson, C.W. Cheng, and S.H. Gregory
World J Gastroenterol, 2009. 15(14): p. 1708-18.
Impact Factor: 3.34 more
<h1 id="page-title" class="highwire-cite-title">Generation of Immune Responses against Hepatitis C Virus by Dendritic Cells Containing NS5 Protein-Coated Microparticles</h1>
Gehring, S., S.H. Gregory, P. Wintermeyer, C. Aloman, and J.R. Wands
Clin Vaccine Immunol, 2009. 16(2): p. 163-71.
Impact Factor: 3.01 more
2008
<h1 class="citation__title">The First Step into the Brain: Uptake of NIO‐PBCA Nanoparticles by Endothelial Cells in vitro and in vivo, and Direct Evidence for their Blood–Brain Barrier Permeation</h1>
Weiss, C.K., M.V. Kohnle, K. Landfester, T. Hauk, D. Fischer, J. Schmitz-Wienke, and V. Mailander
Chemmedchem, 2008. 3(9): p. 1395-1403.
Impact Factor: 2.80 more
<h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver"><span class="title-text">Generation and characterization of an immunogenic dendritic cell population</span></h1>
Gehring, S., S.H. Gregory, P. Wintermeyer, M. San Martin, C. Aloman, and J.R. Wands
J Immunol Methods, 2008. 332(1-2): p. 18-30.
Impact Factor: 1.91 more
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