Contact

Prof. Volker Mailänder

Email:volker.mailaender@unimedizin-mainz.de

University Medical Center of the Johannes Gutenberg University, Mainz

DFG Research Training Group

The planned application for a Research Training Group

Müller LK, Simon J, Rosenauer C, Mailänder V, Morsbach S, Landfester K

The Transferability from Animal Models to Humans: Challenges Regarding Aggregation and Protein Corona Formation of Nanoparticles.

Biomacromolecules. 2018 Feb 12;19(2):374-385. doi: 10.1021/acs.biomac.7b01472.

Zoom Image

Simon J, Wolf T, Klein K, Landfester K, Mailänder V and Wurm FR: Hydrophilicity regulates the stealth properties of polyphosphoester-coated nanocarriers: Angew. Chem. Int. Ed. 10.1002/anie.201800272. Copyright Wiley-VCH Verlag GmbH & Co. KGaA. Reproduced with permission.

ModifyAllergo Talk

Application of the protein corona for therapeutics and diagnostics

Prof. Giulio Caracciolo, Sapienza University of Rome, Italy

23.10.2018, 16:00 o´clock, Seminar Room 1.003, Max Planck Institute for Polymer Research

Center for Translational Nanomedicine

Center for Translational Nanomedicine - CTN

The Max-Planck-Institute for Polymer Research (MPIP) and the University Medicine of the Johannes Gutenberg-University Mainz join forces to create an interdisciplinary center to bring innovative drug delivery systems to the clinic. This bridges the gap between medical need and excellent basic science. Nanocarrier research is focused on altering the body distribution of drugs such that lower doses can be used. This results in lower side effects and/or higher effectiveness. Classical pharmaceutical approaches as well as novel immune modulating agents to treat cancer and (auto)immune diseases like rheumatitis are the focus of the CTN.

Aims:

identify medical needs from applications in clinical use
translate the medical need into a scientific question
understand opportunities and obstacles of nanocarriers in the complex biological surrounding of blood plasma and in whole organisms
to develop a process which uses pharmaceutical grade excipients that can be transformed into a good-manufacturing-production (GMP) process
develop assays for testing of nanocarriers during production and for a batch-to-batch release
perform the crucial in vivo studies for effectiveness and toxicology
transform this towards a process performed in a small-medium enterprise (SME)

How to become a member of CTN?

CTN is in the process of becoming an interdisciplinary working group (“Interdisziplinärer Arbeitskreis – IAK”) according the rules of the JGU. According to these we will form the consortium of the CTN. If you want to express your interest of becoming a member of CTN please contact us by sending your statement of interest to ctn-speaker@ctn.mpg.de

Coordinators:

Prof. Dr. Volker Mailänder, Dermatology Clinic, University Medicine of the Johannes Gutenberg University (JGU), Mainz
Prof. Dr. Katharina Landfester, Physical Chemistry of Polymers, Max Planck Institute for Polymer Research), Mainz
Prof. Dr. Stephan Grabbe, Dermatology Clinic, University Medicine of the Johannes Gutenberg University (JGU), Mainz